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Mg2+对超速驱动后离体大鼠心脏的保护作用
李岩，颜辉 |
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浏览次数 36193 
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| (烟台师范学院 体育学院，山东 烟台 264025） 摘要：为研究Mg2+对疲劳心脏的保护作用，以离体大鼠心脏为研究对象，采用Langendorff灌流装置对超速驱动的离体心脏施加不同浓度Mg2+的灌流液。结果表明，一定浓度的 Mg2+溶液对离体心脏具有明显的保护作用，表现为心肌乳酸脱氢酶漏出减少，谷胱甘肽过氧化物酶活性增高，丙二醛含量降低，心肌组织和线粒体钙超载减轻。 关键词：镁离子； 超速驱动； 离体大鼠心脏 中图分类号：G804.7文献标识码：A文章编号：1006-7116(2004)04-0049-03 |
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Research on the protective function of Mg2+ to the isolated rat heart after overdriving
LI Yan, YAN Hui |
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(Department of Physical Education,Yantai Normal University,Yant ai 264025,China)
Abstract: Taking isolated rat hearts as research objective,with the ad option of Langendorff perfusion device,Mg2+ perfusion solution of varied c oncentration is exerted on the overdriven isolated hearts for the research of th e protective function of Mg2+ towards fatigue hearts. The results indicate that Mg2+ solution of certain concentration possesses tangible protective effect on isolated hearts with performances of the decrease of the transudation of myocardium LDH,the increase of the activity of GSH-PX，the decrease of the c ontent of MDA and the alleviation of the calcium overloading in myocardium and m itochondrion.
Key words: Mg2+； overdriving； isolated rat heart |
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