| （School of Physical Education and Health，East China Normal University，Shanghai 200241，China） Abstract: By working on the molecular structure of mTOR, the authors gave an overview of 4 signal conduction paths (2 mTOR upstream signal paths and 2 mTOR downstream signal paths) that base their center on mTOR. These signal paths play a critical role in the process of signal conduction of motion affecting the skeletal muscle. All these signal systems that cause the change of quality of the skeletal muscle are basing their center on mTOR, and interac-tively connected to form a unified signal conduction network. On the one hand, kinetic skeletal muscle hypertrophy is affected by such two paths as PI3K/Akt/mTOR and PI3K/Akt/TSC12/mTOR; on the other hand, kinetic skeletal muscle atrophy is affected by such a signal conduction path as AMPK/TSC2/mTOR.
Key words: mTOR；signal conduction；skeletal muscle；molecule mechanism；overview |
