|（1.Department of Human Movement and Science；2.Department of Movement and Training，Hebei Institute of Physical Education，Shijiazhuang 050041，China；3.Third Hospital，Hebei Medical University，Shijiazhuang 050011，China）
Abstract: In order to probe into the intrinsic mechanism between flavor preferred learning and sleep deprivation as well as kinetic fatigue, and to seek for a simply practical way to treat kinetic sleep disorder and eliminate fatigue, the authors adopted an immunohistochemical method to observe the change of the expression of β-endorphin in hy-pothalamus of rats after different flavors preferred learning was established, and revealed the following findings: af-ter flavor preferred learning was established, the rats in the exhaustive swimming (ES) group swam longer; there is a significant difference in β-endorphin expression level (Eβ-endorphin) between various groups: after flavor preferred learning the Eβ-endorphin of the rats in the SE group and sleep deprived (SD) group is significantly higher than the Eβ-endorphin of the rats in corresponding ES control group and SD control group; there is no significant difference in Eβ-endorphin between various flavor preferred learning groups and corresponding odor preferred learning groups, as well as between the quinine preferred learning group and corresponding amino acid preferred learning group; the effect of flavor preferred learning on various moderate swimming groups is not significant; Eβ-endorphin shows a pat-tern of synchronous change between the SD group/ES group and corresponding control group. From the said find-ings the following conclusions were drawn: flavor preferred learning, sleep deprivation and swimming training can change the Eβ-endorphin of hypothalamus related nuclear clusters, and their effect varies with stimulation means; in the process of flavor preferred learning, the effect of the taste factor may be greater than the characterizes of stimulants themselves, and the effect of nutrient contents on overall sense is not significant; there might be a common neuro-chemical channel between sleep deprivation and exhaustive exercise in the process of their occurrence and devel-opment. It is hinted that the toxic side effect free pharmacological effect produced by flavor preferred learning can be utilized to delay the adverse process of sleep deprivation and exhaustive exercise, thus performing the function of improving sleep and promoting recovery.
Key words: flavor preferred learning；sleep deprivation；swimming training；hypothalamus；β-endorphin