| （School of Physical Education，South China Normal University，Guangzhou 510006，China） Abstract: Myocardial energy metabolism (MEM) disorder and chronic heart failure (CHF) are concurrently hap-pening and developing, closely related to pathological myocardial hypertrophy and cardiac dysfunction. The authors dissected the MEM characteristics of CHF patients, and gave an overview of progress made in researches on CHF patient’s MEM signaling molecules and regulating paths, as well as the effects of exercising intervention on CHF patient’s MEM related signal regulating paths. In cardiac muscle AMPK, PGC-1α, PKB/Akt and HIF-1α regulate MEM harmoniously via multiple paths. Exercising intervention of CHF patients may affect MEM signaling mole-cules and play an important role in abating CHF patient’s MEM disorder, which will be a new idea for preventing CHF.
Key words: sports physiology；cardiovascular disease；chronic heart failure；myocardial energy metabolism regulation；exercising intervention；overview |
