| （School of Physical Education，South China Normal University，Guangzhou 510006，China） Abstract: More and more evidence indicated that mitochondria play the key role in cadiocyte apoptosis. Many events happened in apoptotic process have been tightly related to mitochondria, including mitochondrial permeabil-ity transition pore(MPTP) open, the depletion of mitochondrial membrane potential (mitochondrial ∆Ψm), mito-chondrial intermembrane space pro-apoptotic protein release, alteration of redox state, Ca2+ overloading, participa-tion of Bcl-2 family and so on. The mitochondrial structure and function and its tight relation to apoptosis were re-viewed, the possible mechanism of mitochondria on cadiocyte apoptosis induced by exercise were also summarized in the article.
Key words: sports medicine；mitochondrial permeability transition pore(mPTP)；mitochondrial intermembrane space；execise；cadiocyte；apoptosis；overview |
