| （1.Sports Rehabilitation Depatrment，Beijing Sport University，Beijing 100084，China；2.Institute of Pharmacology and Toxicology，Academy of Military Medical Sciencet，Beijing 100850，China） Abstract: In order to observe the effects of exercising on the ethological expressions and body weight of chronic stress in-duced depression model rats, the authors replicated depression model rats by means of chronic unpredictable stress (CUS), used fluoxetine (Flu, a classical antidepressant) as a control, observed the effects of medium intensity treadmill running (MIR) and low intensity treadmill running (LIR) on the ethological expressions and body weight of depression model rats in choco-late milk anhedonia experiment, start experiment and novelty inhibition ingestion experiment, and revealed the following findings: 1) ethological study: CUS could significantly lower the degree of addiction of the rats to chocolate milk, reduce their spontaneous activity, and prolong their ingestion latent period in a novel environment; fluoxetine could significant counteract the said changes; with the continuance of exercising, chronic stress had fluoxetine consistent anti depression like behavior functions; 2) body weight change: CUS significantly inhibited the increase of body weight of the rats, Flu, Flu+MIR and Flu+LIR were all unable to improve the slow increase of body weight of CUS rats; MIR and LIR can improve the condition of slow increase of body weight of CUS rats; their weekly body weight had no significant difference as compared with the rats in the CUS group. The said findings proved the followings: depression model rats showed body symptoms of slow body weight increase and depression like ethological expressions such as anhedonia, spontaneous activity slowdown and ingestion latent period prolongation; exercising has fluoxetine consistent anti depression ethological effects on CUS rats.
Key words: sports psychology；sports medicine；chronic stress induced depression model；ethology；body weight；animal experiment |
