|（1.Department of Physical Education，Jinan University，Guangzhou 510630，China；2.School of Physical Education，South China Normal University，Guangzhou 510006，China；3.Huaqiao Hospital，Jinan University，Guangzhou 510630，China）
Abstract: Silent information regulation factor 2 related enzyme I (SIRT1) is a coenzyme NAD+ dependent deace-tylase, not only related to aging, dying and DNA repairing, but also correlative with cellular metabolic transforma-tion in different nutrition stress states. SIRT1 and AMPK are energy receptors in cells, regulating the activity of PGC-1α by means of phosphorylation and deacetylation. The regulation of the activity of the AMPK/SIRT1/PGC-1α axis directly affects the expression of its downstream genes related, being closely related to the occurrence and de-velopment of insulin resistance.
Key words: sports biochemistry；insulin resistance；skeletal muscle；AMPK；SIRT1；PGC-1α；summary