| （Guangzhou Sport University，Guangzhou 510500，China） Abstract: This study is to discuss the anti-inflammatory effect of different intensity exercise, providing new ideas for the treatment of diabetes. Rat model of diabetes were established by high-fat diet with low-dose streptozotocin intraperitoneally injected, and randomly divided into diabetes control group (DMC), and 3 exercising groups (DME1, DME2, DME3). After adapting to treadmill exercise, exercise groups underwent treadmill training at the speed of 10 m/min (DME1)、15 m/min(DME2）and 25 m/min(DME3), 1 h/d, 5 d/week, continuous training for 6 weeks. After 6 weeks, the histopathologic changes of livers were evaluated.the serum ALT, AST, the liver NF-κB content were tested. Results: The exercise group FBG were significant decrease (P<0.01); DME1, DME2 group of GSP decreased significantly (P<0.05, P<0.01); FINS was increase significantly in DME3 Group (P<0.05), and DME1, DME2 and DME3 group there was significant difference (P<0.05); DME1, DME2 group IRI were decreased (P<0.05), while the DME3 groups was increased significantly (P>0.05), and significantly than DME1, DME2 group (P<0.05, P<0.01); the exercise group suffered from hepatic TNF-α decreased to different extent, but only DME2 group was decrease significantly (P<0.01). The Person correlation analysis, liver TNF-α and FPG, IRI is related. Conclusion: Medium-intensity exercise may be better to control blood glucose levels of diabetes and decrease the levels of TNF-α in the liver, thereby improving the status of inflammation in the liver of diabetes, and it is better to prevent and treat diabetic osteoporosis, but its mechanism remains to be further studied.
Key words: exercise biochemistry；diabetes mellitus；liver inflammatory state；TNF-α；treadmill exercise；rats |
