| （1.School of Physical Education，Lanzhou City University，Lanzhou 730070，China；2.Sport Science Research Center，Beijing Sport University，Beijing 100084，China；3.School of Physical Education，Shenzhen University，Shenzhen 518060，China；4.Department of Health & Exercise Science，Tianjin University of Sport，Tianjin 300381，China） Abstract: In order to study the correlations between polymorphic loci rs 131758 and rs 470117 in the carnitine palmityl transferase-1β (CPT-1β) gene region, as well as the haplotype they form, and the changes of sensitivity in-dexes before and after aerobic endurance training, and to probed into the feasibility to use them as sensitivity mark-ers for aerobic endurance training, the authors carried out 18-week aerobic endurance training on 102 youngsters of the Han nationality in northern China, measured “running economization” (RE) related indexes before and after training by using the method of gradually increasing treadmill exercise load, and cardiac structural indexes under different load conditions (at calm, 50W, 100W, 150W, in the recovery period) before and after training by adopting the way of exercising with gradually increased quantitative load under the limit of layback style riding, acquired cardiac function related indexes from cardiac structural indexes, dissected the genotypes of polymorphic loci rs 131758 and rs 470117 of genome DNA of the testees by using the MALDI-TOF MS method, analyzed the correla-tions between the changes of relevant indexes before and after training and the different genotypes of polymorphic loci, and revealed the following findings: 1)type AA of locus rs 131758 was correlative to the training sensitivity of heart rate (ΔHRRE) at running economization after training; 2)type AA of locus rs131758 was correlative to the training sensitivity of left ventricular rear wall thickness (ΔPWS) at the end of systole after training; 3)haplotype AT formed by loci rs 131758 and rs 470117 was correlative to the training sensitivity of stroke output volume index (ΔSVI), cardiac cycle (ΔT) and cardiac output index (ΔCOI) at calm after training. The said findings indicate that type AA of locus rs 131758 and haplotype AT formed by loci rs 131758 and rs 470117 can be used as molecular markers for aerobic endurance training for people of the Nan nationality in northern China.
Key words: sports biochemistry；carnitine palmityl transferase-1β；aerobic endurance；training sensitivity；molecular marker |
