|（1.Key Lab of “Evaluating and Sports Intervening to Adolescent’s Health”of Ministry of Education，East China Normal University，Shanghai 200241，China；2.School of Physical Education and Health，East China Normal University，Shanghai 200241，China；3. School of Physical Education，SIAS International University，Xinzheng 451100，China；
4.School of Physical Education，Anqing Normal University，Anqing 246011，China)
Abstract: The main task of osteoimmunology is to study the mechanism of interaction between the immune system and the skeletal system at cell and molecule levels, under physiological and pathological conditions. This process is extremely complicated, comprising not only bone metabolism regulation made by T cells and B cells, but also the effects of bone immune related factors such as RANKL, TNF-α and IFN-γ etc on bone metabolism. Exercise may affect bone metabolism by regulating the bone immune system, and there are certain differences between different intensities. Medium and low intensity exercise can promote lymphocyte proliferation, up regulate the expression of IFN-γ etc, degrade TRAF 6, further restrain RANKL signal and OC formation; while high intensity exercise can re-strain immune functions, up regulate the expression of factors such as TNF-α and IL, directly or indirectly activate RANKL signal pathway, and promote bone absorption. This study also provides a new idea for enriching the study of the molecular biological mechanism of exercise regulating bone metabolism.
Key words: exercise physiology；bone immune；immune system；bone metabolism；exercise；review