|（1.School of Physical Education and Health，East China Normal University，Shanghai 200241，China；2. Key Lab of “Evaluating and Sports Intervening to Adolescent’s Health”of Ministry of Education，East China Normal University，Shanghai 200241，China)
Abstract: The authors carried out a comprehensive review of exercise and bone endocrine system researches. As a new endocrine organ, bone has endocrine functions. Currently, research priorities are mainly osteocalcin (OCN) and fibroblast growth factor 23(FGF23), in which OCN is carboxylated into uncarboxylated osteocalcin (uOCN), then works on fat cells and islet, thus regulates the secretion of leptin, adiponectin and insulin, and ultimately, works on the bone, forms a feedback circuit, and then regulates energy metabolism. While exercise may affect bone metabo-lism by regulating the bone endocrine system, and different ways of exercise has a different effect on bone endo-crine regulation, especially, the essence of endocrine is to seek for internal environment stability, short-time or one-time exercise is insignificant for the body; long-term exercise can significantly affect corresponding factors while regulating the bone structure, thus stabilize the bone endocrine system. This provides a new idea for exercise improving the molecular biological mechanism of bone and body metabolism.
Key words: exercise biochemistry；osteocalcin；FGF23；review