| （1.Key Laboratory of Adolescent Health Assessment and Exercise Intervention，Ministry of Education，East China Normal University，Shanghai 200241，China；2.Department of Physical Education，Shanghai Jiao Tong University，Shanghai 200240，China) Abstract: Such a single factor as exercise or metformin plays a role in improving the blood glucose homeostasis in T2D, there is contradiction in the effects of exercise combined with metformin on blood glucose homeostasis in T2D: there is a promoting effect, yet there is a retraining effect too, related molecular mechanisms need to be further studied. By reviewing and evaluating the development of researches in this area, the authors analyzed the different effects of exercise combined with metformin on blood glucose homeostasis in T2D, explored and analyzed their causes and possible molecular mechanisms, so as to provide more reference for researches on new treatment targets and programs for treating T2D.
Key words: sports medicine；metformin；exercise; type 2 diabetes；blood glucose homeostasis；review |
