(1. School of Physical Education，South China Normal University，Guangzhou 510006，China；2. School of Physical Education，Huzhou University，Huzhou 313000，China)
Abstract: This study aims to explore effect of aerobic exercise intervention on the activation degree of HPA axis in depressive rats and its upstream regulation mechanism. WKY depressive rats were used as animal models and to carry out 8-week aerobic exercise, and CRH secretion in hypothalamus were used to observe the activation degree of HPA axis, and through expression of Glu and GABA in hippocampus and their receptors in hypothalamus to observe upstream regulation mechanism activated by the HPA axis. The results suggested that: (1) CRH increased significantly in depressive rats, indicating that the HPA axis was over activated, and the mechanism should be directly related to the high expression of Glu in hippocampus and its receptor in hypothalamus, and the low expression of GABA in hippocampus and its receptor in hypothalamus. (2) Exercise intervention lowered HPA axis activation obviously so that the over activation degree of HPA axis could be improved, and the mechanism should be due to down-regulate the expression of Glu in hippocampus and its receptor in hypothalamus, and up-regulate GABA in hippocampus and its receptor in hypothalamus by exercise. (3) Exercise intervention could achieve improvement effect similar to fluoxetine intervention, which shows that aerobic exercise would be an advisable alternative means to replace the treatment of depression by drugs.
Key words: sports biochemistry；depressive rats；aerobic HPA axis；exercise intervention |
