(School of Health and Sports，Xi’an Fanyi University，Xi’an 710105，China)
Abstract: In order to systematically analyze and explore the effects and mechanisms of domestic and foreign sports interventions on the immune response after vaccination in the past 20 years, the results find that acute and chronic exercise interventions before or after vaccination can promote the body's immune system to produce a better immune response to the vaccine, make the titer of the antibody higher after vaccination, and increase faster, as well as have a longer-lasting immune protection effect on the host, especially in the elderly, frail, sick and female populations. At the same time, it can also alleviate the adverse reactions of vaccination. Its mechanism was related to inflammatory environment caused by exercise that can speed up blood circulation, increase the number of white blood cells in the circulating blood, change the content of cytokines or chemokines in the tissues and lymphatic circulation, as well as exercises that cause fine muscle fiber damage. The conclusions are beneficial to understand and participate in the current COVID-19 vaccination for the global population nowadays.
Keywords: sports medicine；immune response；vaccine inoculation；exercise intervention；behavioral adjuvant