体育学刊

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补充抗氧化剂对老年运动小鼠骨骼肌抗氧化水平的影响
卢健，陈彩珍，许永刚，赖荣兴

浏览次数 35970 　

(广州体育学院科研所，广东广州 510075)

摘要：为了解抗氧化剂（维生素E、维生素C和硒）对老年运动小鼠抗氧化能力的影响，给老年运动小鼠补充抗氧化剂（每5 mL饮用水中含VitE 0.25 IU，VitC 0.5 mg、亚硒酸钠0.005 mg）5个月，测定小鼠骨骼肌线粒体及胞浆抗氧化酶活性。结果表明，补充抗氧化剂后运动小鼠骨骼肌CuZnSOD及MnSOD活性下降，胞浆GSH-px活性明显升高，而线粒体GSH-px及胞浆Cat活性无显著性变化，补充抗氧化剂的小鼠骨骼肌线粒体脂褐素含量明显降低。抗氧化剂可适度减轻运动鼠的氧化应激水平。

关键词：抗氧化剂；运动小鼠；抗氧化酶；骨骼肌

中图分类号： G804.7 文献标识码：A 文章编号：1006-7116(2003)04-0058-03

Effect of antioxidant on lipid peroxidation in skeletal muscle of exercise training aged mice
LU Jian, CHEN Cai-zhen, XU Yong-gang, LAI Rong-xing

(Scientific Search Section,Guangzhou Institute of Physical Education, Guangzhou 510075,China)

Abstract:To investigate the effect of antioxidant (Vitamin E, Vitamin C and Selenium) on the antioxidant ability of exercise training aged mice,the present experiment detected antioxidant enzymes activities in mitochondria and cytrol of skeletal muscle after antioxidant supplementation for 5 months. The results showed that compared with control group, CuZnSOD and MnSOD activities in mitochondria decreased, GSH-px in cytrol increased ,while GSH-px in mitochondria and Catalase in cytrol were no significant changes, and the level of Lipofuscin in mitochondria decreased significantly.The results suggested that the oxidant and antioxidant system were in a status of a dynamic equilibrium after antioxidant supplementation.
Key words:antioxidant; exercise mice; antioxidant enzyme; sketelal muscle

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